Inflammatory bowel disease (IBD) describes the life-threatening disorders caused by chronic inflammation of the digestive system. The main types of inflammatory bowel disease include Crohn’s disease (CD) and ulcerative colitis (UC). Both ulcerative colitis (UC) and Crohn’s disease (CD) show up as fatigue, weight loss, abdominal pain, and severe diarrhea.
The new study suggests that inflammatory disease could be determined by some factors like environmental and genetic factors. Gastrointestinal cancer is caused by inflammatory bowel disease (IBD). The researchers are trying to find the therapy for inflammatory bowel disease (IBD) because inflammatory bowel disease (IBD) is difficult to control and has a complex character.
This study was published in the journal Proceedings of the National Academy of Sciences.
A new mechanism in which the pathogenesis of inflammatory bowel disease (IBD) is included and some therapeutics targets for the clinical test are discovered by Professor Liu Jie who is from Huashan Hospital, Fudan University and Professor Sun Bings who is from the Institute of Biochemistry and Cell Biology at Chinese Academy of Sciences.
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The studies conducted by the SUN lab reports all the functions of extracellular matrix protein-1 (ECM1) related to disease in Tfh, Th17, and Th2. The researchers found that the extracellular matrix protein-1 (ECM1) among the inflammatory bowel disease (IBD) was related to ulcerative colitis (UC) in the year 2008. But there is no evidence which indicates the direct role of extracellular matrix protein-1 (ECM1) in inflammatory bowel disease.
The symptoms of inflammatory bowel disease (IBD) depends on the seriousness of inflammation and the part where it happens. The real causes of inflammatory bowel disease (IBD) are still unknown.
In previous studies, stress and diet were considered the causes of inflammatory bowel disease but today’s researches show that these factors can’t cause inflammatory bowel disease (IBD). IBD is not fatal but a serious disease can cause life-threatening problems.
The recent studies show that heredity can also a cause of inflammatory bowel disease (IBD) but many people with inflammatory bowel disease haven’t the family history of IBD. Malfunctioning of the immune system is also a cause of inflammatory bowel disease.
The researchers took some samples of tissues from patients of ulcerative colitis and analyzed them. A DSS-induced inflammatory bowel disease mice model was also analyzed. From this research, it was found that extracellular matrix protein-1 (ECM1) forms more during inflammatory bowel disease progression.
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Tissue infiltrated macrophages express in inflammatory conditions as the more extracellular matrix protein-1 (ECM1) was found in macrophages.
The furthers studies show that extracellular matrix protein-1 (ECM1) can control M1 macrophage polarization with the help of the signaling pathway of GM-CSF/STAT5. Extreme changes in mice with dextran sodium sulfate-induced inflammatory bowel disease were mitigated by the particular drain of extracellular matrix protein-1 (ECM1) gene in the macrophages.
The results obtained from this research shows the presence of GM-CSF/STAT5 in macrophages and expose the participation for the inflammatory bowel disease (IBM) gene in colitis.
