Researchers for many years have found their way to llamas to research their immune systems. Much like human bodies animal bodies too develop antibodies but unlike human antibodies, theirs are single-domain bodies or nanobodies. Therefore, Llamas may help coronavirus treatment with the nanobodies in their immune systems, scientists say.
Nanobodies are stable antibodies and can be ideally stored longterm after production. Inhalers can help them reach the lungs making it an effective treatment for viruses like coronavirus that affect the lungs.
Michael P. Rout, a structural biologist at Rockefeller, finds these antibodies to have amazing properties though researchers don’t understand it yet. The antibody can recognize diseases like human antibodies but are packed into a simple warhead.
This warhead is so much tinier than a human antibody, it measured just to one-tenth of the size in comparison to it.
The industry can easily produce nanobodies as a source of treatments on a massive level. These developing treatments made with nanobodies can make immune systems stronger to specific pathogens.
biochemist Brian T. Chait says millions of people need to be diagnostically tested and doses of therapeutics. Nanobodies could become our greatest, easily available defense against the dangerous coronavirus.
Researchers globally are rushing to make vaccines. In the time before any vaccine makes it to the public an effective treatment is urgently required.
Rout, Chait, and their colleagues believe antibodies from Llamas may help coronavirus treatment. They are extracting from llamas these nanobodies and researching their properties on a molecular level. They are examining such properties so they may find one that is most effective against Covid-19.
Given the little time that has passed since the pandemic began, researchers have a long way to go with the research. The project is still like many others in its initial stage. If it becomes a success, it will help in aiding scientists to further advance treatments and diagnostic tests using these formidable nanobodies.
Rockefeller researchers since early March, have launched 20 projects for coronavirus treatments, this project is one of the 20. They are trying to speed the research on new treatments to aid the world at large if found successful.
Antibodies from Llamas may help coronavirus treatment because of the formation and arrangement of the proteins in their antibodies. Camels among other species of the Camelidae family all make simple successful proteins that help in treatments.
Researchers have high hopes nanobodies of llamas might offer indispensable benefits over antibodies in humans in the fight against COVID-19. Their antibodies are small and may have a better chance of attacking the dense surface of the COVID-19 virus.
It is possible to deploy different nanobodies, each eating away at a different part of the virus. it could be thought of as molecular building blocks and different arrangements can be tried and tested so the virus has no escape.
The collaborators on the team, inject the llamas with coronavirus proteins similarly to how vaccines are given. The subjects don’t get ill and their immune systems are strong enough to produce nanobodies to protect themselves fro the virus.
Antibodies are highly complex and important molecules. In each person, a huge diversity of antibodies is produced, only a few among those proteins is helpful against a pathogen.
Chait praises the Camelid immune systems as being great at producing quality defense against diseases and pathogens, their antibodies being stable and effective.
Rout and Chait use earlier developed methods to efficiently identify nanobody production pipeline and identification. The DNA of antibody making cells is sequenced and isolated. At the same time, the researchers make a point to research the property that helps antibodies bind using mass spectrometry to find the specific properties.
They then make a prepared sample to allow different lab tests to speculate and identify the antibodies as possible aids for drug developments.
Rout says to combat the intensity of the health crisis, they only need a large number of people to try out different things as much as possible and stabilize what terrorizes the world at large.